⚡ Tirzepatide → Retatrutide (Refinetide™) Transition Guide
Transitioning from tirzepatide (Mounjaro/Zepbound/Trimtide™) to retatrutide (Refinetide™)? This calculator helps you find the right starting dose based on your current regimen and tolerance level.
Choose from conservative, moderate, or aggressive transition approaches tailored to your side effect history and experience with GLP-1 medications.
Current Tirzepatide Dose
Select your current Mounjaro, Zepbound, or Trimtide™ weekly dose
Note: Tirzepatide is available as Mounjaro, Zepbound, or Trimtide™. Standard doses range from 2.5–15 mg weekly.
Choose Your Transition Approach
Select based on your tolerance and side effect history
Your Recommended Starting Dose
From 10 mg tirzepatide →
Start Refinetide™ 8 mg
Wait at least 7 days after your last tirzepatide dose before starting retatrutide (Refinetide™)
Refinetide™ is a triple agonist (GLP-1, GIP, glucagon) — expect potentially stronger appetite suppression and metabolic effects than tirzepatide
Monitor for GI side effects during the first 2–4 weeks. Stay hydrated and consider anti-nausea support if needed
If side effects are significant, stay at your current dose for 2+ weeks before considering an increase
Refinetide™ is our premium retatrutide formulation—the newest triple-agonist GLP-1 medication showing superior weight loss results in clinical trials. It's more potent than tirzepatide due to its additional glucagon receptor activity, offering enhanced metabolic benefits and appetite control.
Full Transition Reference
| Current Tirzepatide | Conservative | Moderate | Aggressive |
|---|---|---|---|
| 2.5 mg | Start Refinetide™ 2 mg | — | — |
| 5 mg | Start Refinetide™ 2 mg | Start Refinetide™ 4 mg | — |
| 7.5 mg | Start Refinetide™ 4 mg | Start Refinetide™ 6 mg | Start Refinetide™ 8 mg |
| 10 mg | Start Refinetide™ 4–6 mg | Start Refinetide™ 8 mg | Start Refinetide™ 10 mg |
| 12.5 mg | Start Refinetide™ 6 mg | Start Refinetide™ 8–10 mg | Start Refinetide™ 10–12 mg |
| 15 mg | Start Refinetide™ 8 mg | Start Refinetide™ 10 mg | Start Refinetide™ 12 mg (max) |