⚖️ Semaglutide → Tirzepatide Transition Guide
Transitioning from semaglutide (Ozempic/Wegovy) to tirzepatide (Mounjaro/Zepbound/Trimtide™)? This calculator helps you find the right starting dose based on your current regimen and tolerance level.
Choose from conservative, moderate, or aggressive transition approaches tailored to your side effect history and stability on GLP-1 medications.
Current Semaglutide Dose
Select your current Ozempic or Wegovy weekly dose
Note: Ozempic max is 2.0 mg, Wegovy max is 2.4 mg. Both contain semaglutide.
Choose Your Transition Approach
Select based on your tolerance and side effect history
Your Recommended Starting Dose
From 1 mg semaglutide →
Start Tirzepatide 5 mg
Wait at least 7 days after your last semaglutide dose before starting tirzepatide (or Trimtide™)
Monitor for side effects during the first 2–4 weeks. Common ones include nausea, fatigue, or digestive changes
If you experience significant side effects, stay at your current dose longer before increasing
Trimtide™ is our premium tirzepatide formulation, offering the same active ingredient as Mounjaro/Zepbound with flexible dosing options tailored to your needs.
Full Transition Reference
| Current Semaglutide | Conservative | Moderate | Aggressive |
|---|---|---|---|
| 0.25 mg | Start Tirzepatide 2.5 mg | — | — |
| 0.5 mg | Start Tirzepatide 2.5 mg | Start Tirzepatide 5 mg | — |
| 1 mg | Start Tirzepatide 2.5 mg for 2 weeks, then 5 mg | Start Tirzepatide 5 mg | Start Tirzepatide 7.5 mg |
| 1.7 mg | Start Tirzepatide 5 mg | Start Tirzepatide 7.5 mg | Start Tirzepatide 10 mg |
| 2 mg | Start Tirzepatide 5 mg | Start Tirzepatide 7.5 mg | Start Tirzepatide 10 mg |
| 2.4 mg | Start Tirzepatide 7.5 mg | Start Tirzepatide 10 mg | Start Tirzepatide 12.5–15 mg (only if well tolerated) |